The purpose of this research was to determine the effectiveness of training in decreasing depression and increasing spirituality of marital satisfaction among married women in region 5 in Tehran. This is a kind of quasi- experimental research including experimental group and the control group in which replacing the subjects were divided into two groups randomly. In this study, 30 subjects were recruited and randomly assigned to two experimental and control groups. The experimental group participated in 8 sessions of spiritual training workshop of 90 minutes, and then one week after the last session, the test was administered to both groups. In this study, the Beck Depression Inventory (short form) and Enrich Marital Satisfaction (short form) were used as a measurement tool. Data analysis was used descriptive statistics and inferential statistics were used in the analysis of covariance which was performed through SPSS tool. Testing the hypothesis of the difference between the experimental group and the control variables, depression (with a significance level of p< 0/05), marital satisfaction (with a significance level of p< 0/05), shows statistically significant. The spiritual training decreases depression and increases marital satisfaction in married women. Spiritual interventions such as concentration and meditation, prayer, faith, forgiveness, and other items that were discussed in the context of the group were effective in decreasing depression and increasing marital satisfaction.